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For example, because cefoperazone contains the N methyl thio tetrazole NMTT side chain, which inhibits vitamin K dependent carboxylation, administration of cefoperazone and other NMTT containing cephalosporins can induce alterations in the hepatic glutathione redox state, an increase in oxidized glutathione, and, in turn, inhibition of microsomal reduction of vitamin K epoxide with hypoprothrombinemia and bleeding proscar order best on line pharmacy